Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
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1Cátedra de Patologia General Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Argentina.
Abstract:
Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.
Insights
Foot-and-mouth disease virus (FMDV) causes pancreatic damage in mice. Lidocaine treatment reduced this necrosis and polymorphonuclear leukocyte (PMN) infiltration, suggesting a protective role.
Area of Science:
- Veterinary Pathology
- Virology
- Pharmacology
Background:
- Experimental infection with foot-and-mouth disease virus (FMDV) in mice leads to necrotizing pancreatitis affecting the exocrine pancreas.
- Lesions are characterized by vascular congestion, edema, and infiltration of polymorphonuclear leukocytes (PMNs).
Purpose of the Study:
- To investigate the potential protective effects of lidocaine, a local anesthetic, against FMDV-induced pancreatic necrosis in a mouse model.
- To determine if lidocaine influences the inflammatory response, specifically PMN infiltration, during FMDV infection.
Main Methods:
- Mice were experimentally infected with FMDV.
- Infected mice received varying doses of lidocaine.
- Pancreatic tissue was analyzed for necrosis severity and PMN infiltration.
Main Results:
- Lidocaine treatment resulted in a reduced intensity of pancreatic necrosis in infected mice.
- A significant decrease in the number of PMNs within the infected pancreatic tissue was observed following lidocaine administration.
- The protective effect of lidocaine appears to be linked to the attenuation of PMN infiltration.
Conclusions:
- Lidocaine demonstrates a protective effect against FMDV-induced pancreatic necrosis in mice.
- The mechanism of protection involves the reduction of PMN infiltration into the infected pancreatic tissue.
- Lidocaine may attenuate the inflammatory response, thereby mitigating FMDV-induced pancreatic damage.