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[Urinary infection. I. Comparative in vitro activities of several antibiotic drugs against Gram-negative bacteria]
F Giachino1, A Allocco, L Tuninetti
1Istituto di Microbiologia, Università di Torino.
Abstract:
The in vitro activity of imipenem against 3,496 Gram-negative strains isolated from 4,505 positive urocultures was determined. The effectiveness of imipenem was then compared with that of ampicillin, amoxycillin + clavulanic acid, ticarcillin, piperacillin, aztreonam, cefalotin , ceftazidime, cefoxitin, cefotaxime, norfloxacin, ciprofloxacin, amikacin, gentamicin, tobramycin, trimethoprim + sulfamethoxazole. Imipenem was active against all isolates, including Pseudomonas spp. known to account for a large portion of nosocomial infections and resistance to antibacterial drugs.
Insights
Imipenem demonstrated excellent in vitro activity against Gram-negative bacteria from urine cultures, including resistant Pseudomonas species. This broad-spectrum antibiotic offers a promising option for treating challenging urinary tract infections.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Urinary tract infections (UTIs) are frequently caused by Gram-negative bacteria.
- Nosocomial infections and antibiotic resistance, particularly from Pseudomonas species, pose significant treatment challenges.
- Evaluating the efficacy of broad-spectrum antibiotics is crucial for effective UTI management.
Purpose of the Study:
- To determine the in vitro activity of imipenem against Gram-negative bacteria isolated from positive urocultures.
- To compare the effectiveness of imipenem with other commonly used antibiotics for UTIs.
Main Methods:
- In vitro susceptibility testing was performed on 3,496 Gram-negative bacterial isolates from 4,505 positive urocultures.
- Imipenem's activity was compared against a panel of antibiotics including ampicillin, amoxicillin/clavulanic acid, ticarcillin, piperacillin, aztreonam, cefalotin, ceftazidime, cefoxitin, cefotaxime, norfloxacin, ciprofloxacin, amikacin, gentamicin, tobramycin, and trimethoprim/sulfamethoxazole.
Main Results:
- Imipenem exhibited activity against all tested Gram-negative isolates.
- Notably, imipenem was effective against Pseudomonas species, a common cause of nosocomial infections and antibiotic resistance.
- The study provides comparative data on imipenem's in vitro performance against various antimicrobial agents.
Conclusions:
- Imipenem demonstrates potent in vitro activity against a wide range of Gram-negative uropathogens.
- Its effectiveness against resistant strains like Pseudomonas spp. highlights its potential as a valuable therapeutic option for complicated UTIs.
- These findings support the role of imipenem in combating difficult-to-treat bacterial infections of the urinary tract.