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Linkage and the limits to natural selection

N H Barton1

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom.

Genetics
|June 1, 1995
PubMed
Summary
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THE PROBABILITY OF FIXATION OF A NEW KARYOTYPE IN A CONTINUOUS POPULATION.

Evolution; international journal of organic evolution·2017

Genetic variation in fitness, caused by linked mutations, reduces favorable mutation fixation probability. This hitchhiking effect impedes adaptation, especially for weakly favored alleles in large populations.

Area of Science:

  • Evolutionary genetics
  • Population genetics

Background:

  • Favorable mutation fixation is crucial for adaptation.
  • Genetic background variation can influence fixation probability.

Purpose of the Study:

  • To develop a general method for calculating allele fixation probability.
  • To assess the impact of linked selection on adaptation.

Main Methods:

  • Applied a general method to calculate fixation probability.
  • Analyzed effects of substitutions, fluctuating polymorphisms, and deleterious mutations.
  • Investigated effects under loose and tight linkage.

Main Results:

  • Loose linkage effects depend on additive genetic variance in fitness, reducing effective population size.

Related Experiment Videos

  • Tightly linked loci have unpredictable effects.
  • Linked deleterious mutations and substitutions significantly reduce fixation probability for weakly favored alleles.
  • Fluctuating polymorphisms also impede fixation.

    • Conclusions:

    • Hitchhiking from linked selection substantially hinders adaptation.
    • Weakly favored alleles are particularly vulnerable to impeded fixation.