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Proliferative activity in metastatic malignant melanoma: comparison of pre-treatment and post-treatment metastases
S K Barksdale1, J B Stern, H M Haupt
1Laboratory of Pathology, National Institutes of Health, Bethesda, MD 20892, USA.
Journal of Cutaneous Pathology
|August 1, 1995
Abstract:
In this study, the proliferative activity of malignant melanoma metastases was assessed before and after isolated limb perfusion chemotherapy by quantitating AgNORs, mitoses and PCNA activity. No significant difference in either AgNOR count, mitotic activity or PCNA index was observed. We conclude that AgNOR count, mitotic activity and PCNA index were not significantly effected by isolated limb perfusion chemotherapy.