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Related Experiment Videos

Histologic findings in acute HIV exanthem

G D Goldman1, L M Milstone, P E Shapiro

  • 1Section of Dermatology, Veterans Administration Hospital, West Haven, CT, USA.

Journal of Cutaneous Pathology
|August 1, 1995
PubMed
Summary

This study details a patient with acute HIV exanthem presenting with papulovesicular lesions and epidermal necrosis. Literature review reveals common histopathology includes perivascular lymphocytic infiltrate, with potential for spongiosis, vacuolar alteration, or necrosis.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pathology

Background:

  • Acute HIV exanthem is a common manifestation of early HIV infection.
  • Understanding its dermatopathologic features is crucial for diagnosis.

Observation:

  • A case of acute HIV exanthem with papulovesicular lesions and epidermal necrosis is presented.
  • Histopathologic examination revealed specific epidermal and dermal changes.

Findings:

  • The most common finding in acute HIV exanthem is a perivascular lymphocytic infiltrate.
  • Associated findings can include spongiosis, vacuolar alteration, and epidermal necrosis, as seen in this patient.

Implications:

  • Recognizing these histopathologic variations aids in diagnosing acute HIV infection.

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  • This case highlights the spectrum of cutaneous manifestations and their underlying pathology.