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Histologic findings in acute HIV exanthem
G D Goldman1, L M Milstone, P E Shapiro
1Section of Dermatology, Veterans Administration Hospital, West Haven, CT, USA.
Journal of Cutaneous Pathology
|August 1, 1995
Summary
This study details a patient with acute HIV exanthem presenting with papulovesicular lesions and epidermal necrosis. Literature review reveals common histopathology includes perivascular lymphocytic infiltrate, with potential for spongiosis, vacuolar alteration, or necrosis.
Area of Science:
- Dermatology
- Infectious Diseases
- Pathology
Background:
- Acute HIV exanthem is a common manifestation of early HIV infection.
- Understanding its dermatopathologic features is crucial for diagnosis.
Observation:
- A case of acute HIV exanthem with papulovesicular lesions and epidermal necrosis is presented.
- Histopathologic examination revealed specific epidermal and dermal changes.
Findings:
- The most common finding in acute HIV exanthem is a perivascular lymphocytic infiltrate.
- Associated findings can include spongiosis, vacuolar alteration, and epidermal necrosis, as seen in this patient.
Implications:
- Recognizing these histopathologic variations aids in diagnosing acute HIV infection.
- This case highlights the spectrum of cutaneous manifestations and their underlying pathology.