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Related Experiment Videos

Reversible AIDS-related sclerosing cholangitis

J P Teare1, D A Price, G R Foster

  • 1Department of Medicine, St. Mary's Hospital, Medical School, Imperial College of Science Technology and Medicine, London, UK.

Journal of Hepatology
|August 1, 1995
PubMed
Summary

Acquired immunodeficiency syndrome (AIDS) can cause liver issues, but rarely affects the bile ducts. This case shows diffuse B-cell lymphoma causing sclerosing cholangitis in an HIV-infected man, which resolved with chemotherapy.

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Area of Science:

  • Hepatology
  • Oncology
  • Infectious Diseases

Background:

  • Hepatobiliary involvement is common in patients with acquired immunodeficiency syndrome (AIDS).
  • Biliary tract abnormalities are infrequent complications of human immunodeficiency virus (HIV) infection.
  • Early diagnosis and treatment are crucial for managing HIV-associated complications.

Observation:

  • A 39-year-old man with HIV infection presented with malaise, right upper quadrant pain, lymphadenopathy, and cholestasis.
  • Endoscopic retrograde cholangiopancreatography revealed sclerosing cholangitis.
  • The sclerosing cholangitis was attributed to disseminated B-cell non-Hodgkin's lymphoma.

Findings:

  • Disseminated B-cell non-Hodgkin's lymphoma was identified as the cause of sclerosing cholangitis in an HIV-infected patient.

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  • Chemotherapy led to rapid improvement in the patient's symptoms and clinical signs.
  • Follow-up endoscopic retrograde cholangiopancreatography demonstrated complete resolution of the biliary abnormalities within one month.

    • Implications:

    • This case highlights a rare presentation of HIV-associated biliary tract disease.
    • It underscores the importance of considering hematologic malignancies in the differential diagnosis of cholestasis in HIV-infected individuals.
    • Successful treatment of the underlying lymphoma resulted in complete reversal of the biliary abnormalities, demonstrating the potential for favorable outcomes with prompt diagnosis and therapy.