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Antidepressant-induced orgasm disorder

R T Segraves1

  • 1Case Western Reserve University, Cleveland, OH, USA.

Journal of Sex & Marital Therapy
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Most antidepressants cause anorgasmia, a common sexual side effect. Strategies to manage this include dose changes or switching medications, potentially due to serotonin receptor interactions.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Sexual Medicine

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are widely prescribed.
  • Drug-induced anorgasmia is a frequent and distressing side effect associated with many antidepressant medications.
  • Bupropion and nefazodone may be exceptions regarding anorgasmia induction.

Purpose of the Study:

  • To review the association between antidepressants and anorgasmia.
  • To discuss common management strategies for antidepressant-induced anorgasmia.
  • To explore the potential neurobiological mechanisms underlying this side effect.

Main Methods:

  • Literature review of antidepressant-induced sexual dysfunction.
  • Analysis of clinical evidence regarding management strategies.

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  • Examination of proposed neurochemical pathways involved in orgasm.

    • Main Results:

    • Most US-approved antidepressants, excluding bupropion and nefazodone, are linked to anorgasmia.
    • Effective management strategies include dose adjustment, regimen changes, medication substitution, or combination therapy.
    • Evidence suggests 5HT2 antagonism interfering with adrenergic orgasm mechanisms may be involved.

    Conclusions:

    • Antidepressant-induced anorgasmia is a significant clinical issue.
    • Various strategies can be employed to mitigate this side effect.
    • Serotonergic and adrenergic pathways are implicated in the pathophysiology of antidepressant-induced anorgasmia.