Jove
Visualize
Contact Us

Related Experiment Videos

Constitutional and acquired trisomy 8

L M Secker-Walker1, M Fitchett

  • 1Department of Haematology, Royal Free Hospital School of Medicine, London, U.K.

Leukemia Research
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients.

Leukemia & lymphoma·2016
Same author

A new parental cell line for human x human hybridoma production.

Cytotechnology·2012
Same author

Prenatal diagnosis of cri du chat (5p-) syndrome in association with isolated moderate bilateral ventriculomegaly.

Prenatal diagnosis·2002
Same author

The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management.

British journal of haematology·2001
Same author

Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia.

Leukemia·2000
Same author

Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia.

Leukemia·1999
Same journal

Multispecialty referral patterns to a clonal hematopoiesis clinic: Who, what, and why?

Leukemia research·2026
Same journal

A multicenter real-world study of clinical outcomes in octogenarians and older patients with acute myeloid leukemia.

Leukemia research·2026
Same journal

FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

Leukemia research·2026
Same journal

CD244 modulates bone marrow infiltrating CD8<sup>+</sup> T cells and serves as a prognostic and immunotherapeutic target in acute myeloid leukemia.

Leukemia research·2026
Same journal

Long-term remission and survival in older adults with IDH-mutated acute myeloid leukemia treated with IDH inhibitors.

Leukemia research·2026
Same journal

Real-world outcomes of plasmablastic lymphoma: Treatment approaches and survival outcomes in the PLASMABLAT-001 cohort.

Leukemia research·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Trisomy 8, a chromosomal abnormality, can be inherited or acquired. A case study highlights how constitutional trisomy 8 mosaicism can evolve into myelodysplasia, impacting diagnosis.

Area of Science:

  • Genetics
  • Hematology
  • Oncology

Background:

  • Trisomy 8 is a chromosomal abnormality observed in both constitutional and acquired disorders.
  • Constitutional trisomy 8 typically presents with physical stigmata, skeletal issues, and intellectual disability.
  • Acquired trisomy 8 is associated with hematological malignancies like myelodysplasia (MDS) and acute myeloid leukemia (AML), affecting malignant cells.

Purpose of the Study:

  • To analyze a case of constitutional trisomy 8 mosaicism that developed into myelodysplasia.
  • To discuss the diagnostic implications of this case for both malignant and constitutional conditions.

Main Methods:

  • Case report analysis.
  • Review of literature on trisomy 8 and its associated disorders.

Related Experiment Videos

Main Results:

  • A patient with constitutional trisomy 8 mosaicism developed myelodysplasia with trisomy 8 present in 95-100% of bone marrow cells.
  • This case highlights the potential overlap and diagnostic challenges between constitutional and acquired trisomy 8 conditions.

Conclusions:

  • The presented case underscores the importance of considering the evolution of trisomy 8 from a mosaic constitutional state to a more aggressive acquired hematological disorder.
  • Accurate diagnosis requires careful evaluation to differentiate between constitutional and acquired forms of trisomy 8, especially in patients with hematological abnormalities.