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Abnormal sensory nerve conduction in multifocal demyelinating neuropathy with persistent conduction block
J Valls-Solé1, A Cruz Martinez, F Graus
1Servicio de Neurologia, Hospital Clinic of Barcelona, Spain.
Neurology
|November 1, 1995
Summary
This study details two patients with multifocal neuropathy with conduction block (MNCB), a rare nerve disorder. Findings suggest that sensory nerve fibers can also be affected in MNCB, expanding the understanding of this condition.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Multifocal neuropathy with conduction block (MNCB) is a rare disorder characterized by motor conduction block.
- The involvement of sensory fibers in MNCB has been less understood.
Observation:
- Two patients presented with chronic, asymmetric upper limb weakness, muscle wasting, and fasciculations.
- Electrophysiological studies revealed multifocal conduction block in unusual nerve segments, delayed F waves, and abnormal thenar responses to magnetic stimulation.
Findings:
- Needle electromyography showed chronic denervation with large polyphasic motor units.
- Despite normal sensory nerve conduction studies, somatosensory evoked potentials indicated sensory pathway involvement.
- Lower limb electrophysiology was largely normal.
Implications:
- These cases demonstrate that sensory fibers can be affected in multifocal neuropathy with conduction block.
- This expands the clinical and electrodiagnostic spectrum of MNCB.
- Highlights the importance of comprehensive electrophysiological testing in diagnosing MNCB.