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Related Experiment Videos

Sleeping sickness and the central nervous system

V W Pentreath1, P J Baugh, D R Lavin

  • 1Department of Biological Sciences, University of Salford, United Kingdom.

The Onderstepoort Journal of Veterinary Research
|December 1, 1994
PubMed
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Chronic African trypanosomiasis causes progressive behavioral deficits due to central nervous system (CNS) pathology. This includes inflammation, blood-brain barrier damage, and altered signaling substances, leading to neurological impairment.

Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • Chronic African trypanosomiasis presents with significant behavioral deficits.
  • The underlying pathology involves complex central nervous system (CNS) changes.

Purpose of the Study:

  • To detail the neuropathology associated with chronic African trypanosomiasis.
  • To elucidate the mechanisms linking CNS pathology to behavioral deficits.

Main Methods:

  • Review of existing literature on CNS pathology in African trypanosomiasis.
  • Analysis of cellular and molecular changes in the brain.

Main Results:

  • Early meningitis progresses to choroid plexus breakdown and parasite invasion.

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  • Encephalitis involves widespread inflammation, blood-brain barrier damage, and reactive glial cells.
  • Perturbation of cytokine/mediator networks, including prostaglandins, is observed.

    • Conclusions:

    • The neuropathology of chronic African trypanosomiasis is multifactorial, involving inflammation and immune responses.
    • Altered signaling substances in the cerebrospinal fluid contribute to behavioral changes like hypersomnia.
    • Understanding CNS immunopathology is crucial for managing trypanosomiasis-associated neurological disorders.