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Basic principles in selecting animal species for research projects

H C Hughes, C M Lang

    Clinical Toxicology
    |December 1, 1978
    PubMed
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    Choosing the right laboratory animal model is crucial for biomedical research success. Key considerations include model type, handling, cost, and biological factors like genotype and physiology.

    Area of Science:

    • Biomedical Research
    • Animal Models in Research

    Background:

    • Selecting appropriate animal models is a critical step in biomedical research.
    • Four main categories of animal models exist: experimental, spontaneous, negative, and orphan.

    Purpose of the Study:

    • To outline the essential criteria for selecting the optimal laboratory animal species for research purposes.
    • To highlight the diverse factors influencing animal model choice in scientific investigations.

    Main Methods:

    • Review of established practices and considerations in laboratory animal selection.
    • Categorization of animal models into four distinct types.
    • Identification of practical and biological factors for investigator consideration.

    Main Results:

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    • Experimental models are most common, but all categories have research applications.
    • Selection requires evaluating handling ease, size, cost, and investigator familiarity.
    • Biological factors such as disease resistance, nutrition, and physiology are also vital.

    Conclusions:

    • A systematic approach considering both practical and biological aspects ensures appropriate animal model selection.
    • Informed choice of animal models directly impacts the validity and success of biomedical research outcomes.