High-level quinolone resistance in Neisseria gonorrhoeae: a report of two cases
J W Tapsall1, E A Limnios, C Thacker
1Microbiology Department, Prince of Wales Hospital, Sydney, Australia.
Background And Objectives:
Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported.
Study Design:
This is a case report.
Conclusion:
High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.
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