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Related Experiment Videos

Methotrexate-induced leukoencephalopathy. A case report

I Ilhan1, A Cila, M Büyükpamukçu

  • 1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.

The Turkish Journal of Pediatrics
|July 1, 1995
PubMed
Summary

Intrathecal methotrexate, used to treat non-Hodgkin's lymphoma, can cause severe central nervous system damage, including leukoencephalopathy, as seen in a pediatric patient. This case highlights the critical need for monitoring adverse effects of chemotherapy.

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Area of Science:

  • Neuroscience
  • Oncology
  • Pharmacology

Background:

  • Non-Hodgkin's lymphoma treatment often involves chemotherapy agents like methotrexate.
  • Intrathecal (IT) methotrexate is administered directly into the cerebrospinal fluid for certain cancers.
  • Methotrexate can have significant central nervous system (CNS) side effects.

Observation:

  • A six-year-old girl with non-Hodgkin's lymphoma received both intravenous (IV) and IT methotrexate.
  • The patient developed neurological complications, including hypertension, altered body temperature, lethargy, and coma.
  • Magnetic resonance imaging (MRI) revealed bilateral white matter hyperintensities in the occipital lobes.

Findings:

  • The observed clinical presentation and MRI findings are consistent with treatment-related leukoencephalopathy.

Related Experiment Videos

  • Leukoencephalopathy is a known adverse effect of IT methotrexate, typically presenting in a generalized form.
  • This case presents a focal manifestation of methotrexate-induced leukoencephalopathy.

    • Implications:

    • This case underscores the potential for focal CNS toxicity from IT methotrexate, even in pediatric patients.
    • Close monitoring for neurological adverse events during and after methotrexate therapy is crucial.
    • Further research may be needed to understand the mechanisms and risk factors for focal leukoencephalopathy in response to methotrexate treatment.