Characterization of chromosome 11 with a complex inversion and deletion in an AML [M2] using fluorescence in situ...

We report on a new case of AML [M2] where chromosome 11 was rearranged in a highly complex manner involving band 11q23. Routine G banding failed to identify the nature of this aberration which later was accomplished using whole chromosome 11-specific painting probe by the FISH technique. Chromosome 11 band q23 is frequently involved in reciprocal translocations with various chromosomes, but to have sole morbidity of such a complex nature is an atypical finding in AML [M2]. The band q23 of chromosome 11 involves the mixed lineage leukemia gene and rearrangement of this chromosomal region has been found in a variety of neoplasias. Henceforth, its precise identification has become imperative for classification of hematological malignancies and in turn to devise therapeutic strategies.