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Chemokines and renal disease
1Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882, USA.
Summary
Chemokines, inflammatory cytokines, attract immune cells like neutrophils and monocytes. Their role in kidney disease suggests potential therapeutic targets for renal pathology.
Area of Science:
- Immunology
- Nephrology
- Cell Biology
Background:
- Chemokines are small proteins that direct immune cell movement.
- They are classified into C-X-C (alpha) and C-C families, targeting neutrophils and monocytes, respectively.
- Chemokine receptors are G protein-coupled receptors crucial for cell signaling.
Purpose of the Study:
- To review the role of chemokines in renal disease.
- To highlight the involvement of chemokines in immune cell infiltration in the kidney.
- To discuss the therapeutic potential of targeting chemokines in kidney pathology.
Main Methods:
- Review of existing literature on chemokines and renal disease.
- Analysis of chemokine expression patterns in kidney tissues.
- Discussion of in vivo neutralization studies using antibodies.
Main Results:
- Chemokines are induced by proinflammatory cytokines and produced by various kidney cells.
- Evidence supports chemokine involvement in neutrophil and mononuclear cell infiltration in glomeruli and interstitium.
- Chemokine expression is elevated in renal disease, contributing to pathology and proteinuria.
Conclusions:
- Chemokines play a significant role in mediating renal pathology and proteinuria.
- Interleukin-8, RANTES, and monocyte chemotactic peptide are key chemokines in kidney disease.
- Targeting chemokines and their receptors offers promising therapeutic avenues for renal diseases.