Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C associated glomerulonephritis

I H Altraif1, A S Abdulla, M I al Sebayel

  • 1King Fahad National Guard Hospital, Riyadh, Saudi Arabia.

American Journal of Nephrology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Just an unfair score: Perceptions of gender inequity in the treatment of substance use disorders among women involved in the criminal legal system.

Journal of substance use and addiction treatment·2024
Same author

Opioid and stimulant attributed treatment admissions and fatal overdoses: Using national surveillance data to examine the intersection of race, sex, and polysubstance use, 1992-2020.

Drug and alcohol dependence·2023
Same author

Daily opioid and stimulant co-use and nonfatal overdoses in the context of social disadvantage: Findings on marginalized populations.

Journal of substance use and addiction treatment·2023
Same author

Social Networks, Stigma, and Hepatitis C Care Among Women Who Inject Drugs: Findings from A Community Recruited Sample.

Journal of psychoactive drugs·2022
Same author

Racial differences in overdose training, naloxone possession, and naloxone administration among clients and nonclients of a syringe services program.

Journal of substance abuse treatment·2021
Same author

Feline immunodeficiency virus and feline leukemia virus: frequency and associated factors in cats in northeastern Brazil.

Genetics and molecular research : GMR·2017
Same journal

Metabolic Syndrome and Risk of Atrial Fibrillation in Chronic Kidney Disease.

American journal of nephrology·2026
Same journal

Premature Aortic Stiffness in Relation to Cerebral Small Vessel Disease, Cognitive Decline, Major Cardiovascular Events and Mortality in Dialysis.

American journal of nephrology·2026
Same journal

Adjudicating heart failure as an end point in dialysis trials- more signal, less noise.

American journal of nephrology·2026
Same journal

Bridging the Evidence-to-Practice Gap in Hypertension: Why Innovation Isn't Always Implementation.

American journal of nephrology·2026
Same journal

Adjudicating Heart Failure Events in Participants Receiving Hemodialysis: Findings from Evaluation of Cinacalcet Hydrochloride Therapy to Lower Cardiovascular Events (EVOLVE) Trial.

American journal of nephrology·2026
Same journal

Beyond the Amount: The Selectivity of Proteinuria and Risk of Graft Failure in Kidney Transplant Recipients.

American journal of nephrology·2026
See all related articles

Hepatitis C virus (HCV) cirrhosis is linked to a high prevalence of glomerulonephritis (GN), a kidney disease. This study found 21% of patients had GN, including new associations, highlighting the need for further research.

Area of Science:

  • Nephrology
  • Hepatology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease and cirrhosis.
  • Glomerulonephritis (GN) is a potential extrahepatic manifestation of HCV, but its prevalence in HCV cirrhosis is not well-defined.
  • Kidney involvement in HCV cirrhosis can complicate management and affect patient outcomes.

Purpose of the Study:

  • To determine the prevalence and specific types of glomerulonephritis (GN) in patients with hepatitis C virus (HCV) cirrhosis.
  • To investigate the clinical presentation and pathological findings of GN in this population.
  • To explore potential therapeutic interventions for HCV-associated GN.

Main Methods:

  • Prospective evaluation of 28 consecutive Saudi patients with HCV cirrhosis undergoing assessment for liver transplantation.

Related Experiment Videos

  • Kidney biopsies were performed in patients with proteinuria or elevated serum creatinine.
  • Histopathological, immunologic, and electron microscopic studies were conducted on biopsy samples.

    • Main Results:

    • Six patients (21%) were diagnosed with GN.
    • The types of GN observed were membranoproliferative (4 patients), focal segmental (1 patient), and membranous (1 patient).
    • Immune complex deposition was confirmed in the glomeruli of affected patients. Focal segmental GN is reported as a novel association with HCV.

    Conclusions:

    • HCV cirrhosis is associated with a significant prevalence of glomerulonephritis.
    • The findings suggest immune complex-mediated GN is a complication of HCV cirrhosis.
    • Interferon alpha therapy showed potential benefit in patients with significant proteinuria and HCV-associated GN.