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Postcaesarean section uterovesical fistula lined by persistent intermediate trophoblast
S M Ismail1, C G Lewis, R W Shaw
1Department of Pathology, University of Wales College of Medicine, Cardiff, Wales.
The American Journal of Surgical Pathology
|December 1, 1995
Summary
A rare uterovesical fistula after caesarean section was found lined by intermediate trophoblast. This finding suggests third-trimester trophoblast can survive independently of pregnancy.
Area of Science:
- Gynecology
- Pathology
- Reproductive Biology
Background:
- Post-caesarean section complications can include fistulas.
- Uterovesical fistulas are rare, particularly those lined by trophoblastic tissue.
Observation:
- A 42-year-old woman presented with cyclical haematuria one year after a caesarean section.
- A uterovesical fistula was diagnosed and surgically excised.
Findings:
- Microscopic examination revealed the fistula tract was lined by intermediate trophoblast.
- These cells exhibited characteristic features including abundant eosinophilic cytoplasm, multiclefted nuclei, and positive staining for cytokeratins and human placental lactogen.
Implications:
- This represents a novel finding, previously undescribed in medical literature.
- The survival of third-trimester intermediate trophoblast appears independent of the pregnancy state.