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Circulating leukocyte adhesion molecules in stable asthma and nonobstructive chronic bronchitis
G C Riise1, S Larsson, O Löwhagen
1Department of Pulmonary Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Allergy
|August 1, 1995
Summary
Circulating cell adhesion molecules (cCAMs) like ICAM-1, VCAM-1, and E-selectin are not reliable biomarkers for stable asthma or chronic bronchitis airway inflammation. Their levels did not differ significantly across patient groups in this study.
Area of Science:
- Immunology
- Pulmonology
- Biochemistry
Background:
- Leukocyte adhesion molecules are implicated in airway inflammatory diseases.
- Circulating cell adhesion molecules (cCAMs) can be measured in body fluids.
- Elevated cCAMs have been observed in acute asthma and chronic bronchitis.
Purpose of the Study:
- To determine if cICAM-1, cVCAM-1, and cE-selectin patterns indicate airway inflammation in stable asthma and nonobstructive chronic bronchitis.
- To assess cCAMs as potential biomarkers for stable airway inflammatory conditions.
Main Methods:
- Serum and bronchial lavage (BL) fluid analyzed from controls, asthmatics (with/without steroid therapy), and chronic bronchitis patients.
- Quantification of circulating intercellular adhesion molecule-1 (cICAM-1), vascular cell adhesion molecule-1 (cVCAM-1), and E-selectin (cE-selectin).
Main Results:
- cICAM-1, cVCAM-1, and cE-selectin were detected in serum of patients with stable asthma and chronic bronchitis.
- Only cICAM-1 was found in BL fluid.
- No significant differences in cCAM levels were observed between subject groups; ECP levels were higher in non-steroid-treated asthmatics.
Conclusions:
- Circulating ICAM-1, VCAM-1, and E-selectin do not appear to be strongly associated with the degree of airway inflammation in stable asthma or nonobstructive chronic bronchitis.
- cCAMs are not effective biomarkers for assessing stable airway inflammation in these conditions.