Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pontine infarction with diffuse myelin destruction

N Takahata, H Suzuki, R Fukatsu

    Folia Psychiatrica Et Neurologica Japonica
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Purification and characterization of DNA topoisomerase IV in Escherichia coli.

    The Journal of biological chemistry·1992
    Same author

    Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats.

    The Journal of biological chemistry·1992
    Same author

    Inhibition of cell attachment, invasion and metastasis of human carcinoma cells by anti-integrin beta 1 subunit antibody.

    Japanese journal of cancer research : Gann·1992
    Same author

    Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat.

    Neuroscience research·1992
    Same author

    Alpha-fetoprotein-producing immature mediastinal teratoma showing rapid and massive recurrent growth in an adult.

    Acta pathologica japonica·1992
    Same author

    Ki-67 antibody labeling index in colorectal carcinoma.

    Journal of clinical gastroenterology·1992

    Cerebral arteriosclerosis and pontine myelin destruction were observed in a patient with dementia and spastic paraplegia. These findings suggest vascular disease may contribute to neurological deficits.

    Area of Science:

    • Neuropathology
    • Vascular Neurology
    • Neurodegenerative Diseases

    Background:

    • Dementia and spastic paraplegia are complex neurological conditions.
    • Cerebral arteriosclerosis is a common finding in elderly populations.
    • The basis pontis is a critical brainstem structure involved in motor control and consciousness.

    Observation:

    • A 57-year-old male presented with clinical symptoms of dementia and spastic paraplegia.
    • Pathological examination revealed scattered cerebral arteriosclerotic changes.
    • Diffuse myelin destruction was noted in the basis pontis, accompanied by fibrous gliosis, neuronal loss, and axonal loss.

    Findings:

    • The observed pontine myelin destruction was associated with significant fibrous gliosis and loss of neurons and axons.

    Related Experiment Videos

  • Pontine infarction was identified as a potential cause of the extensive myelin damage.
  • The pathological changes resembled those seen in certain demyelinating conditions.

    • Implications:

    • This case highlights the potential role of cerebral arteriosclerosis and associated pontine pathology in the development of dementia and spastic paraplegia.
    • Understanding these vascular contributions is crucial for accurate diagnosis and treatment of complex neurological syndromes.
    • Further research into the link between vascular disease and demyelination in the brainstem may reveal new therapeutic targets.