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Influence of 2-chloro-2'-deoxyadenosine alone and in combination with cyclophosphamide or methotrexate on murine
J Góra-Tybor1, T Robak, K Warzocha
1Department of Pharmacology, Medical Academy, Lódź, Poland.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1994
Abstract:
The influence of 2-CdA administrated alone and in combination with CY or MTX on the survival time of mice bearing L1210 leukemia was investigated. 2-CdA treated mice lived longer than control animals. Survival times of mice receiving combined therapy of 2-CdA and CY were significantly prolonged as compared with mice treated with these agents separately. Survival times of mice treated with 2-CdA and MTX were not significantly prolonged, compared with animals receiving 2-CdA alone.