In vitro primary antitumor screen of imidazole platinum complexes

The cytostatic activity in vitro of six cis-platinum analogs with imidazole ligands was examined. The tests were performed on 60 lines of human neoplastic cells in the NCI Preclinical Antitumor Drug Screening Program. The results obtained from 10 the most sensitive lines were analyzed and the structure-activity relationship was deduced. The cytotoxic activity of the active complexes seems to correlate with the hydrophobic properties of neutral imidazole ligands and with kinetic properties of anionic ligands.