[Antigenic determinants of proteins. The humoral immune response]

There exist two opposing points of view on the organization of antigenic determinants of proteins: 1) the determinants are stringently predetermined regions of the protein molecule; 2) all the surface of the protein globule is potentially antigenic, and the immune response is generated occasionally in every individual, although some sites of the protein surface could be preferable for eliciting the immune response. In this work, taking into account the results of recent investigations, we propose some reconciliation: a correlation between the rigidity of the protein architecture and the antigenicity of the particular sites of the antigen molecule. Some general principles of the antigenic determinants of proteins are formulated.