Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating adhesion molecules in tuberculosis

C K Lai1, K C Wong, C H Chan

  • 1Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong.

Clinical and Experimental Immunology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of forefoot strike and toe-out running on hip contact forces: A musculoskeletal modelling-based study.

Journal of biomechanics·2025
Same author

Efficient biodiesel production by sulfonated carbon catalyst derived from waste glycerine pitch via single-step carbonisation and sulfonation.

Waste management (New York, N.Y.)·2024
Same author

Links between socio-demographic characteristics and body mass index to colorectal cancer in North Borneo, Malaysia: A case-control study.

The Medical journal of Malaysia·2023
Same author

Alterations in the Choroidal Sublayers in Relationship to Severity and Progression of Diabetic Retinopathy: A Swept-Source OCT Study.

Ophthalmology science·2022
Same author

Development of the rural Palliative Care Services by the Kuala Lipis District Hospital.

The Medical journal of Malaysia·2021
Same author

The many facets of neuropathic arthropathy.

BJR open·2020

Active tuberculosis patients show elevated levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin. Circulating ICAM-1 is a promising marker for identifying active tuberculosis disease.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Biochemistry

Background:

  • Leucocyte-endothelial adhesion molecules are crucial in inflammatory disease pathogenesis.
  • Their role as disease activity markers in tuberculosis requires investigation.

Purpose of the Study:

  • To evaluate serum concentrations of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and vascular cell adhesion molecule-1 (VCAM-1) as markers of tuberculosis disease activity.

Main Methods:

  • Antigen capture ELISA was used to measure serum levels of ICAM-1, E-selectin, and VCAM-1.
  • Study included 34 active tuberculosis patients, 15 treated patients, and 27 healthy volunteers.

Main Results:

  • Circulating ICAM-1 and E-selectin were significantly elevated in active tuberculosis patients compared to treated patients and healthy controls.

Related Experiment Videos

  • VCAM-1 was elevated in active or old pulmonary tuberculosis but not in tuberculous lymphadenitis.
  • Circulating ICAM-1 demonstrated the highest discriminative power for active tuberculosis, elevated in approximately 80% of patients.

    • Conclusions:

    • Three adhesion molecules may be involved in tuberculosis pathogenesis.
    • Circulating ICAM-1 shows potential as a useful marker for active tuberculosis disease activity.