Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Septic shock: pathogenesis and treatment

L Castillo1, M Sanchez

  • 1Pediatric Unit, Massachusetts General Hospital, Boston 02114.

Indian Journal of Pediatrics
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Web-application guided bimodal olfactory training for COVID-19 patients: a randomized trial.

Rhinology·2025
Same author

Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors.

ESMO open·2025
Same author

Impact of electronic immunization registries and electronic logistics management information systems in four low-and middle-income countries: Guinea, Honduras, Rwanda, and Tanzania.

Vaccine·2025
Same author

Responders to biologics in severe uncontrolled chronic rhinosinusitis with nasal polyps: a multicentric observational real-life study.

Rhinology·2024
Same author

Tubomanometry: An effective and promising assessment of Eustachian tube dysfunction in chronic rhinosinusitis patients.

European annals of otorhinolaryngology, head and neck diseases·2020
Same author

French Otorhinolaryngology Society (SFORL) good practice guidelines for dental implant surgery close to the maxillary sinus.

European annals of otorhinolaryngology, head and neck diseases·2019
Same journal

Beyond Proteinuria: Does Growth Matter in Childhood Nephrotic Syndrome?

Indian journal of pediatrics·2026
Same journal

Impulse Oscillometry for Pulmonary Function Evaluation in Children with Neuromuscular Disease: A Comparative Study with Spirometry - Correspondence.

Indian journal of pediatrics·2026
Same journal

Impact of Enzyme Replacement Therapy on Patients with Late Onset Pompe Disease - Real World Data from a Developing Country.

Indian journal of pediatrics·2026
Same journal

Reciprocal Interaction Loss During Screen-Assisted Feeding: The Dominant Language Risk Component in Early Childhood.

Indian journal of pediatrics·2026
Same journal

Bilateral Parotid Enlargement as an Initial Manifestation of Pediatric Acute Lymphoblastic Leukemia.

Indian journal of pediatrics·2026
Same journal

Hemorrhagic Cardiac Tamponade Due to MRSA Sepsis in a Child with Relapsed Acute Lymphoblastic Leukemia: Authors' Reply.

Indian journal of pediatrics·2026
See all related articles

Septic shock, an inflammatory response to infection, involves mediators like cytokines. Early diagnosis and hemodynamic stability are key for managing this condition and improving patient outcomes.

Area of Science:

  • Critical care medicine
  • Pathophysiology
  • Immunology

Background:

  • Septic shock is a severe host inflammatory response to infection.
  • Multiple endogenous mediators, including cytokines, nitric oxide, and prostaglandins, drive its pathogenesis.
  • Early diagnosis and treatment are facilitated by the concept of sepsis syndrome.

Purpose of the Study:

  • To summarize the pathogenesis of septic shock.
  • To outline current management strategies.
  • To highlight the importance of organ-system support and emerging therapies.

Main Methods:

  • Review of endogenous mediators involved in septic shock.
  • Discussion of diagnostic criteria and clinical management principles.
  • Exploration of organ-system specific care and experimental therapeutic approaches.

Related Experiment Videos

Main Results:

  • Identified key mediators such as cytokines, nitric oxide, and prostaglandins in septic shock pathogenesis.
  • Emphasized the critical role of hemodynamic stability and oxygen delivery in management.
  • Highlighted the necessity of vigilant organ-system monitoring to prevent complications.

Conclusions:

  • Septic shock management requires a multifaceted approach focusing on hemodynamic support and organ function.
  • Understanding the role of inflammatory mediators is crucial for therapeutic development.
  • Experimental therapies targeting the inflammatory response show promise for improved outcomes.