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Related Experiment Videos

Urinary prostate specific antigen levels after radical prostatectomy

T K Takayama1, R L Vessella, M K Brawer

  • 1Department of Urology, University of Washington, Seattle.

The Journal of Urology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Urinary prostate specific antigen (PSA) after prostatectomy primarily comes from the urethra, not residual prostate tissue. Serial urinary PSA measurements have limited value for monitoring recurrence in these patients.

Area of Science:

  • Urology
  • Oncology
  • Biochemistry

Background:

  • Urinary prostate specific antigen (PSA) levels can be discordant with serum PSA post-radical prostatectomy.
  • This discordance has led to speculation about early disease recurrence indicated by elevated urinary PSA.
  • Understanding the source of urinary PSA is crucial for accurate patient monitoring after prostatectomy.

Purpose of the Study:

  • To investigate the source of urinary PSA in patients following radical prostatectomy.
  • To evaluate the correlation between urinary PSA, serum PSA, and pathological factors.
  • To assess the utility of serial urinary PSA measurements for monitoring disease recurrence.

Main Methods:

  • Measured urinary PSA in patients post-radical prostatectomy and cystoprostatectomy.

Related Experiment Videos

  • Analyzed initial stream and end stream voided urine samples for PSA levels.
  • Assessed PSA levels in urethral swab samples and performed immunohistochemical analysis on urethrectomy specimens.

    • Main Results:

    • No correlation found between urinary PSA, serum PSA, pathological stage, or operation type.
    • PSA levels in end stream urine samples were significantly lower than initial stream samples.
    • High levels of PSA were detected in urethral swabs and washes, with positive PSA staining in urethrectomy specimens.

    Conclusions:

    • The urethra is the primary source of urinary PSA after total prostatectomy, not residual prostate tissue.
    • Serial urinary PSA measurements have limited value in monitoring patients post-radical prostatectomy.
    • Further investigation is needed to determine if urethral PSA can contaminate serum PSA levels.