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Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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Related Experiment Video

Updated: May 19, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

Juxtacrine intercellular signaling: another way to do it

G A Zimmerman¹, D E Lorant, T M McIntyre

¹Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City.

American Journal of Respiratory Cell and Molecular Biology

|December 1, 1993

Summary

Juxtacrine intercellular signaling involves cell-to-cell communication via membrane-bound molecules, crucial for regulated biological processes. Disruption of this signaling can lead to disease, highlighting its importance in health and development.

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Last Updated: May 19, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

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Published on: July 16, 2013

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Published on: February 26, 2017

A Proximal Culture Method to Study Paracrine Signaling Between Cells

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Area of Science:

Cellular Biology
Developmental Biology
Physiology

Background:

Intercellular communication is vital for morphogenesis, development, inflammation, and organ repair.
Juxtacrine signaling, a form of cell-to-cell communication, involves membrane-bound signaling molecules.
This contrasts with endocrine and paracrine signaling, which act in the fluid phase.

Purpose of the Study:

To review the general principles of juxtacrine intercellular signaling.
To discuss specific examples of juxtacrine signaling in biological contexts.
To highlight the importance of juxtacrine signaling in regulated physiological events.

Main Methods:

Literature review of juxtacrine signaling mechanisms.
Analysis of juxtacrine signaling in various biological processes.
Discussion of the implications of juxtacrine signaling disruption.

Main Results:

Juxtacrine signaling provides precise spatial control of cell activation.
This signaling mechanism is essential for tightly regulated physiological events.
Disruption of juxtacrine signaling is linked to pathological outcomes.

Conclusions:

Juxtacrine signaling is a fundamental mechanism for controlled intercellular communication.
Understanding juxtacrine signaling is critical for comprehending normal development and disease.
Further research into juxtacrine signaling pathways can reveal therapeutic targets.