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Ifosfamide-induced renal tubular defect
M J Torres Valdivieso1, J López Pérez, C Melero
1Department of Pediatric Hematology-Oncology, Social Security Hospital 12 de Octubre, Madrid, Spain.
Medical and Pediatric Oncology
|January 1, 1994
Abstract:
We describe 2 cases of proximal tubular defects induced by the administration of ifosfamide at a dosage of 6 g/m2/course over 2 days in children with a diagnosis of malignant mesenchymal tumors. This adverse effect could be minimized dividing dosage of the drug. However at present it is not clear if divided doses are completely safe.