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[Hepatitis C: from pathogenesis to treatment]
1Hôpital du Samaritain, Vevey.
Insights
Hepatitis C virus (HCV), a Flaviviridae family member, is a primary cause of non-A, non-B hepatitis. This article details the diagnosis, progression, and treatment of acute hepatitis C.
Area of Science:
- Virology
- Hepatology
Context:
- Hepatitis C virus (HCV) is a significant cause of non-A, non-B hepatitis.
- Antibodies against HCV are detected in 60-100% of post-transfusion non-A, non-B hepatitis patients.
- The potential involvement of a second virus in non-A, non-B hepatitis remains under investigation.
Purpose:
- To present the diagnosis of Hepatitis C virus infection.
- To outline the clinical course of Hepatitis C.
- To describe the treatment strategies for Hepatitis C.
Summary:
- Hepatitis C virus (HCV), belonging to the Flaviviridae family, is implicated in most cases of non-A, non-B hepatitis.
- Serological evidence confirms persistent HCV antibodies in a high percentage of transfusion-associated non-A, non-B hepatitis.
- While HCV is a common cause of sporadic acute hepatitis, the existence of a second causative agent cannot be ruled out.
Impact:
- Provides essential information for diagnosing and managing Hepatitis C.
- Contributes to understanding the epidemiology of non-A, non-B hepatitis.
- Informs clinical practice regarding the treatment of acute hepatitis C.
Abstract:
Hepatitis C virus (HCV) belongs to the greater family of Flaviviridae. It is probably responsible for the majority of NANB hepatitis. Serologic evidence in the term of antibodies against certain parts of HCV persists in 60 to 100% of patients with NANB hepatitis after blood transfusion. The evidence for the existence of a second virus responsible for NANB has not been excluded as inactivation-studies would suggest. HCV is also a common cause for sporadic acute hepatitis. It is the purpose of this article to present diagnosis, course and treatment of this form of hepatitis.