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Related Experiment Videos

How neurotransmitters affect axoplasmic transport?

T Takenaka1, T Kawakami, Y Bandou

  • 1Department of Physiology, Yokohama City University, Japan.

The Japanese Journal of Physiology
|January 1, 1993
PubMed
Summary

Acetylcholine (ACh) and adrenaline modulate fast axoplasmic transport in neurons. These neurotransmitters influence neuronal activity by altering transport rates via cyclic AMP (c-AMP) levels.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Fast axoplasmic transport is crucial for neuronal function.
  • Neurotransmitters like acetylcholine (ACh) and adrenaline play roles in neuronal signaling.
  • The regulation of axoplasmic transport by these neurotransmitters is not fully understood.

Purpose of the Study:

  • To investigate the effects of acetylcholine (ACh) and adrenaline on fast axoplasmic transport.
  • To elucidate the role of cyclic AMP (c-AMP) in mediating these effects.
  • To understand the relationship between neurotransmitter-controlled transport and neuronal activity.

Main Methods:

  • Utilized a computer-assisted video-enhanced differential interference contrast microscopy system.
  • Analyzed fast axoplasmic transport in cultured superior cervical ganglion cells.

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  • Quantified the effects of ACh and adrenaline on anterograde and retrograde transport.

    • Main Results:

    • Acetylcholine (ACh) reversibly suppressed fast axoplasmic transport in both anterograde and retrograde directions.
    • Adrenaline reversibly increased fast axoplasmic transport rates.
    • Both effects were correlated with changes in intracellular cyclic AMP (c-AMP) levels.

    Conclusions:

    • Neurotransmitters acetylcholine (ACh) and adrenaline dynamically regulate fast axoplasmic transport.
    • Cyclic AMP (c-AMP) acts as a key intracellular mediator for these transport modulations.
    • The control of axoplasmic transport by neurotransmitters is intrinsically linked to overall neuronal activity.