Polarographic reduction and carcinogenic index tg alpha of 5-aza nucleosides possessing antileukemic activity
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A Vachálková1, L Novotný, A Pískala
1Department of Experimental Therapy, Slovak Academy of Sciences, Bratislava.
Neoplasma
|January 1, 1993
Abstract:
Polarographic behavior of arabinosyl-5-azacytosine (ara-AC) and 5-azacytidine in anhydrous dimethylformamide and in Britton Robinson buffer is described. 5-Azacytidine and ara-AC underwent two-electron reduction under the polarographic conditions used. Carcinogenic index tg alpha estimated in the presence of alpha-lipoic acid was 0.295 for 5-azacytidine and 0.275 for ara-AC.