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Nimesulide does not interfere with airway responsiveness in allergic asthma
V Brusasco1, E Crimi, I Scaricabarozzi
1Dipartimento di Scienze Motorie, Università di Genova, Italy.
Drugs
|January 1, 1993
Summary
Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), appears safe for asthma patients allergic to house dust mites. It does not worsen asthma symptoms or airway responsiveness when exposed to allergens.
Area of Science:
- Pharmacology
- Allergology
- Pulmonology
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) can exacerbate asthma by increasing leukotriene production.
- Nimesulide, an NSAID with weak prostaglandin synthetase inhibition, is hypothesized to be safer for asthmatics.
Purpose of the Study:
- To evaluate the safety and effects of nimesulide in asthmatic patients with house dust mite allergy.
- To determine if nimesulide alters bronchial response to allergens or airway responsiveness.
Main Methods:
- The study involved asthmatic patients allergic to house dust mite.
- Patients were assessed for bronchial response to allergen and airway responsiveness after nimesulide administration.
Main Results:
- Nimesulide did not alter the bronchial response to allergen in these patients.
- Nimesulide did not aggravate the allergen-induced increase in airway responsiveness.
Conclusions:
- Nimesulide appears to be a safe NSAID option for managing asthma in patients with house dust mite allergy.
- Further research can explore nimesulide's role in managing NSAID-exacerbated respiratory disease.