Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent studies on the characterization of loop diuretics

G Giebisch1, G Klein-Robbenhaar

  • 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Journal of Cardiovascular Pharmacology
|January 1, 1993
PubMed
Summary

This study surveys transport in the loop of Henle and how loop diuretics affect electrolyte excretion. It details ion transport, channels, and regulation in the thick ascending limb, plus downstream effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Some electrical properties of single renal tubule cells.

The Journal of general physiology·2009
Same author

Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis.

European journal of clinical pharmacology·2009
Same author

Renal and extrarenal regulation of potassium.

Kidney international·2007
Same author

Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet.

Kidney international·2006
Same author

Role of luminal anion and pH in distal tubule potassium secretion.

American journal of physiology. Renal physiology·2003
Same author

Remembrances of renal potassium transport.

The Journal of membrane biology·2002

Area of Science:

  • Nephrology
  • Renal Physiology
  • Pharmacology

Background:

  • The loop of Henle plays a critical role in renal electrolyte and water reabsorption.
  • Loop diuretics are essential in managing fluid overload and electrolyte imbalances.
  • Understanding transport mechanisms is key to optimizing diuretic therapy.

Purpose of the Study:

  • To survey transport mechanisms in the loop of Henle.
  • To investigate the secondary effects of loop diuretics on electrolyte excretion.
  • To evaluate the impact of potassium depletion and acidosis on diuretic potency.

Main Methods:

  • Experimental definition of ion transport in the thick ascending limb.
  • Summarization of data on ion channels and transport regulation.

Related Experiment Videos

  • Survey of mechanisms of enhanced sodium chloride and water transport downstream of the loop of Henle.

    • Main Results:

    • Detailed ion transport mechanisms in the thick ascending limb were elucidated.
    • New data on ion channels and regulatory processes were presented.
    • Downstream effects of diuretics on electrolyte and water transport were surveyed.

    Conclusions:

    • The study provides comprehensive insights into loop of Henle transport and diuretic action.
    • Understanding these mechanisms aids in predicting and managing diuretic efficacy.
    • Further research into torasemide's effects, including potential antialdosterone actions, is warranted.