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Related Experiment Videos

[Ofloxacin concentration in prostatic tissue]

A Kawauchi1, K Kamoi, T Ohne

  • 1Department of Urology, Kyoto Prefectural University of Medicine.

Hinyokika Kiyo. Acta Urologica Japonica
|December 1, 1993
PubMed
Summary

This study found that ofloxacin effectively penetrates prostatic tissue, reaching a peak concentration 4.5 hours after oral administration. This suggests ofloxacin is a promising treatment for prostatitis.

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Area of Science:

  • Pharmacology
  • Urology

Context:

  • Benign prostatic hypertrophy (BPH) is a common condition.
  • Prostatitis, an inflammation of the prostate, can be acute or chronic.
  • Evaluating drug penetration into specific tissues is crucial for effective treatment.

Purpose:

  • To determine the concentration of ofloxacin in prostatic tissue and serum.
  • To evaluate the permeability of ofloxacin into prostatic tissue in patients with BPH.
  • To assess the potential of ofloxacin for treating prostatitis.

Summary:

  • Ofloxacin was administered orally at 200 mg to patients undergoing prostatectomy for BPH.
  • Prostatic tissue and serum levels were measured, with peak prostatic concentration at 1.46 microgram/g occurring 4.5 hours post-administration.

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  • The ratio of prostatic tissue to serum ofloxacin levels was 1.00.

    • Impact:

    • Ofloxacin demonstrates good penetration into prostatic tissue.
    • The findings support the use of ofloxacin for treating acute and chronic prostatitis.
    • This research contributes to understanding antibiotic efficacy in genitourinary infections.