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Stabilization of inducible nitric oxide synthase by monoclonal antibodies
R Hattori1, K Kosuga, H Eizawa
1Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Hybridoma
|December 1, 1993
We have produced 14 monoclonal antibodies to inducible nitric oxide synthase purified from rat peritoneal cytotoxic activated macrophages. None of the antibodies showed neutralizing activity, but some of them enhanced the enzyme activity through stabilization of the enzyme.
We have produced 14 monoclonal antibodies to inducible nitric oxide synthase purified from rat peritoneal cytotoxic activated macrophages. None of the antibodies showed neutralizing activity, but some of them enhanced the enzyme activity through stabilization of the enzyme.