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Related Experiment Videos

Peptidergic nerves in the ureter

A Godet1, P M Heidger, H N Winfield

  • 1Department of Urology, University of Iowa College of Medicine, Iowa City.

Journal of Endourology
|October 1, 1993
PubMed
Summary

Vasoactive intestinal peptide (VIP) nerves are present in pig ureters, primarily near smooth muscle. VIP induces ureteral relaxation, suggesting its role in regulating smooth muscle tone in both normal and obstructed conditions.

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Area of Science:

  • Urology
  • Neuroscience
  • Gastroenterology

Background:

  • Vasoactive intestinal peptide (VIP) and substance P are neuropeptides found in the urinary tract.
  • Their precise role in ureteral function, particularly smooth muscle tone regulation, requires further elucidation.

Purpose of the Study:

  • To investigate the presence and distribution of VIP and substance P in the pig ureter.
  • To determine the functional effect of VIP on ureteral smooth muscle activity in normal and obstructed states.

Main Methods:

  • Immunohistochemical techniques were employed to visualize VIP and substance P.
  • Isolated ureteral segments (normal and obstructed) were used to assess the relaxant effects of VIP in vitro.

Main Results:

  • VIP and substance P-containing nerves were identified predominantly in the smooth muscle layer of the pig ureter.
  • VIP induced significant relaxation in isolated ureteral segments at concentrations above 0.18 µg/ml.
  • VIP's relaxant effect was comparable in both normal and obstructed ureteral tissues.

Conclusions:

  • VIP is present in ureteral nerves associated with smooth muscle.
  • VIP acts as a relaxant on ureteral smooth muscle.
  • VIP may play a significant role in regulating ureteral smooth muscle tone, irrespective of obstruction.

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