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An intestinal natriuretic factor

G C Hansson1, J Y Mu, O Lundgren

  • 1Department of Medical Biochemistry, University of Göteborg, Sweden.

Journal of Cardiovascular Pharmacology
|January 1, 1993
PubMed
Summary
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Scientists discovered a natriuretic factor in the gastrointestinal tract that influences kidney sodium excretion. This intestinal factor, with a molecular mass of 500-1,000 Da, shows greater effects in spontaneously hypertensive rats.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Physiology

Background:

  • Previous research suggested the gastrointestinal tract can sense sodium intake and influence kidney sodium excretion.
  • The existence and nature of an intestinal natriuretic factor remained uncharacterized.

Purpose of the Study:

  • To investigate the presence and characteristics of an intestinal natriuretic factor.
  • To determine if intestinal tissue contains a substance that augments renal sodium excretion.

Main Methods:

  • Intestinal tissue from cats was homogenized and fractionated using ultrafiltration and gel chromatography (Sephadex G25).
  • Fractions were assayed for natriuretic activity in anesthetized rats.
  • Active fractions were further purified using cation exchange chromatography.

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Main Results:

  • A fraction with an apparent molecular mass of 500-1,000 Da significantly increased renal sodium and water excretion.
  • This natriuretic activity was eluted at 250 mM NaCl using ion exchange chromatography.
  • Preliminary data indicate a more pronounced effect in spontaneously hypertensive rats (SHR) compared to Wistar-Kyoto (WKY) rats.

Conclusions:

  • The study identified a low molecular weight (500-1,000 Da) natriuretic factor in the gastrointestinal tract.
  • This factor appears to modulate renal sodium excretion, with potential implications for hypertension research.
  • Further investigation is warranted to fully elucidate the role of this intestinal factor in sodium balance and blood pressure regulation.