[Dextran-induced anaphylactoid reaction (DIAR). 2 clinical cases]

Area of Science:

• Medical research
• Clinical case reports
• Pharmacology

Background:

• Dextran is a glucose polymer used medically for plasma volume expansion.
• Anaphylactoid reactions are non-immunologic hypersensitivity responses.
• The Ring e Messmer classification grades the severity of anaphylactoid reactions.

Observation:

• Two patients presented with anaphylactoid reactions to dextran.
• The reactions were classified as grade II and grade III severity.
• Metabolic acidosis was observed as an early clinical sign.

Findings:

• Dextran administration can precipitate severe anaphylactoid reactions.
• Metabolic acidosis is an early and critical symptom in dextran-induced anaphylactoid reactions.
• The severity of these reactions necessitates careful patient monitoring.

Implications:

• Clinicians should be vigilant for metabolic acidosis in patients receiving dextran.
• Early recognition of metabolic acidosis can guide immediate therapeutic interventions.
• This highlights the importance of considering dextran as a potential cause of anaphylactoid reactions and associated acidosis.