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Related Experiment Videos

Does atrial fibrillation cause false-positive late potentials?

T A Buckingham1, M M Radin, A S Volgman

  • 1Department of Medicine, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612-3864.

Pacing and Clinical Electrophysiology : PACE
|December 1, 1993
PubMed
Summary
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Atrial fibrillation does not significantly affect signal-averaged ECG parameters used to detect late potentials. Conversion to normal sinus rhythm did not alter these measurements, suggesting atrial activity does not cause false positives.

Area of Science:

  • Electrophysiology
  • Cardiology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia.
  • Late potentials on signal-averaged ECGs (SAECG) can indicate risk for ventricular arrhythmias.
  • Atrial activity in AF might lead to false-positive late potentials.

Purpose of the Study:

  • To investigate if atrial fibrillation causes false-positive late potentials on SAECGs.
  • To assess changes in SAECG parameters after conversion of AF to normal sinus rhythm.

Main Methods:

  • Signal-averaged ECGs were recorded in 26 patients with AF before and after cardioversion.
  • Standard SAECG criteria were used: filtered QRS duration (fQRS), low amplitude signal (LAS) duration, and terminal QRS root mean square (RMS).
  • Late potentials were defined by specific fQRS, LAS, and RMS thresholds.

Related Experiment Videos

Main Results:

  • No significant differences were observed in fQRS, LAS, RMS, or noise levels between AF and sinus rhythm.
  • The presence of late potentials did not significantly change after cardioversion (10 in AF vs. 9 in sinus rhythm).
  • Individual patient SAECGs showed minor variations but no consistent pattern related to rhythm conversion.

Conclusions:

  • Signal-averaged ECG parameters are not significantly altered by the presence of atrial fibrillation.
  • Cardioversion of atrial fibrillation to normal sinus rhythm does not substantially change SAECG findings.
  • Atrial activity during AF is unlikely to cause clinically significant false-positive late potentials.