Related Experiment Video
Updated: Aug 14, 2026
11:55
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Continuous infusion ABDIC therapy for relapsed or refractory Hodgkin's disease
M R Smith1, P S Khanuja, A al-Katib
1Department of Internal Medicine, Wayne State University School of Medicine, Harper Hospital, Detroit, Michigan.
Cancer
|February 15, 1994
Summary
The ABDIC chemotherapy regimen shows activity and tolerability in refractory Hodgkin
Area of Science:
- Oncology
- Hematology
- Clinical Trials
Background:
- Hodgkin's disease refractory to standard chemotherapy has a poor prognosis.
- Bone marrow transplantation is considered for chemo-sensitive refractory disease.
Purpose of the Study:
- To evaluate the efficacy and tolerability of the ABDIC regimen in patients with relapsed or refractory Hodgkin's disease.
Main Methods:
- 19 patients received the modified Hagemeister ABDIC regimen (doxorubicin, bleomycin, dacarbazine, lomustine, prednisone) every 28 days.
- Continuous infusion of doxorubicin and dacarbazine was utilized.
Main Results:
- A 63% overall response rate was observed, with 12 partial and 2 complete responses.
- Two patients achieved long-term disease-free survival after subsequent bone marrow transplantation.
- Treatment was generally well tolerated, with nausea and bone marrow suppression as main toxicities.
Conclusions:
- The ABDIC regimen is an active and well-tolerated therapy for relapsed/refractory Hodgkin's disease, even in patients previously treated with ABVD.
- ABDIC followed by bone marrow transplantation offers potential for long-term disease-free survival in heavily pretreated patients.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
01:30Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
01:25Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...