Hyaline globules in ovarian tumours

Area of Science:

• Gynecologic Pathology
• Tumor Biology
• Histopathology

Background:

• Hyaline eosinophilic globules are uncommon findings in specific tumor types.
• Their presence in gynecologic malignancies, particularly ovarian tumors, has been noted.
• Limited data exists on their incidence and distribution across various gynecologic neoplasms.

Purpose of the Study:

• To investigate the incidence and distribution of hyaline eosinophilic globules.
• To analyze their occurrence in malignant, borderline, and benign epithelial ovarian tumors.
• To examine their presence in endometrial and endocervical adenocarcinomas.

Main Methods:

• Histopathological examination of 30 mixed Müllerian tumors, ovarian tumors (malignant, borderline, benign), endometrial, and endocervical adenocarcinomas.
• Staining with Periodic Acid-Schiff (PAS) after diastase and PTAH.
• Immunoreactivity assessment for alpha-1-antitrypsin.

Main Results:

• Globules were found in all 30 mixed Müllerian tumors.
• High incidence in clear cell (22/30) and serous (7/30) ovarian carcinomas.
• Low incidence in borderline and benign ovarian tumors; absent in Brenner tumors, endometrial, and endocervical adenocarcinomas.
• Globules were PAS-positive (diastase-resistant) and stained positively for alpha-1-antitrypsin.

Conclusions:

• Hyaline eosinophilic globules are not specific to any single tumor type.
• Their high frequency in malignant mixed Müllerian tumors is significant.
• The presence of these globules in female genital tract epithelial tumors necessitates careful exclusion of malignant mixed Müllerian tumors.