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Related Experiment Videos

A pseudo outbreak of tuberculosis

P Shears1, L E Rhodes, Q Syed

  • 1Royal Liverpool Children's Hospital.

Communicable Disease Report. CDR Review
|January 7, 1994
PubMed
Summary

A suspected tuberculosis outbreak in an oncology unit was investigated. The outbreak was likely caused by a contaminated phenol red solution, not actual tuberculosis cases.

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Area of Science:

  • Medical Microbiology
  • Infectious Disease Epidemiology
  • Oncology

Background:

  • An apparent tuberculosis outbreak was identified in an oncology unit over a 10-day period.
  • Initial case finding resulted in the diagnosis of nine suspected tuberculosis cases.

Purpose of the Study:

  • To critically evaluate an outbreak investigation of suspected tuberculosis.
  • To identify the root cause of the apparent "outbreak" and prevent future occurrences.

Main Methods:

  • Review of the initial outbreak investigation procedures.
  • Detailed investigation of laboratory protocols and reagents.

Main Results:

  • The investigation revealed that the suspected tuberculosis 'outbreak' was likely a false positive due to a contaminated phenol red solution.
  • No evidence of actual tuberculosis transmission was found among the oncology patients.

Conclusions:

  • Contaminated laboratory reagents can mimic infectious disease outbreaks.
  • Critical evaluation of outbreak investigations and interdisciplinary collaboration are essential for accurate diagnosis and patient safety.

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