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Related Experiment Videos

Solid cell nests of the thyroid. A histologic and immunohistochemical study

Y Mizukami1, A Nonomura, T Michigishi

  • 1Pathology Section, Kanazawa University Hospital, Japan.

American Journal of Clinical Pathology
|February 1, 1994
PubMed
Summary

Solid cell nests (SCN) found in thyroid glands likely originate from the ultimobranchial body. Immunohistochemical analysis revealed specific cellular markers supporting this origin and diverse cellular functions.

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Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Histology

Background:

  • Solid cell nests (SCN) are incidental findings in thyroid glands.
  • Their precise origin and cellular lineage remain incompletely understood.

Purpose of the Study:

  • To investigate the histogenesis of SCN using histologic and immunohistochemical methods.
  • To determine the cellular origin of SCN within the thyroid gland.

Main Methods:

  • Histologic examination of 11 surgically obtained thyroid glands containing SCN.
  • Immunohistochemical analysis of SCN for various cellular markers including calcitonin, CEA, calcitonin gene-related peptide, chromogranin A, and keratin.

Main Results:

  • SCN exhibited solid and cystic structures, with mucinous material and goblet cells observed in some cases.

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  • Immunohistochemistry showed widespread positivity for keratin (100%) and carcinoembryonic antigen (CEA) (100% with polyclonal antibody).
  • Other markers like calcitonin and chromogranin A were positive in 45% of cases, suggesting varied cellular expression.

    • Conclusions:

    • The findings strongly support the derivation of SCN from the ultimobranchial body.
    • Individual cells within SCN may possess diverse biologic functions related to antigen production.