Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation
L Bjermer1, T Sandström, B Särnstrand
1Department of Lung Medicine, University Hospital, Umeå, Sweden.
American Journal of Industrial Medicine
|January 1, 1994
Abstract:
A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.
