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Tenascin: does it play a role in epidermal morphogenesis and homeostasis?
1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Abstract:
Tenascin is a large glycoprotein of the extracellular matrix. Its complex multidomain structure, along with its unique distribution during embryogenesis, inflammation, wound healing, and tumorigenesis suggest this protein may play a significant role in regulating cell proliferation, migration, and differentiation. In this review I will summarize the structural features of tenascin and its localization in skin and discuss some of the potential roles of tenascin in the regulation of keratinocyte biology.
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