[Neurohumoral induction of structural and functional compensatory reorganization of the damaged brain]

A correlation has been found between the time course of the biological activity of specific oligo- and polypeptide factors in cerebrospinal fluid and the effectiveness of motor function recovery. The fluid as a donor material accelerates the compensatory process in recipient animals with unilateral neocortical damage. The procedure stimulates the formation process of connections of the centrally denervated semisegments of the spinal cord with the somatosensory cortex of the intact brain hemisphere. Endolumbar introduction of cerebrospinal fluid from reconvalescents induced the regress of symptoms of central motor disorders in patients with stroke sequelae.