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Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma
J K Yamamoto1, M L Kruzel, H Louie
1Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1993
Abstract:
The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha).