Micronucleus formation in fetal maternal rat erythroblasts after norfloxacin transplacental administration
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1Institute of Pharmacology, University of Genoa, Italy.
Mutation Research
|April 1, 1994
Abstract:
Single oral doses of norfloxacin (4, 2, 1, 0.5 mmole/kg) administered to pregnant rats significantly increase the frequency of micronucleated polychromatic erythrocytes both in fetal liver and in maternal bone marrow. Therefore norfloxacin in this work has been found to be a genotoxic agent.