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Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation
S Sardaş1, B Karahalil, A E Karakaya
1Gazi University, Faculty of Pharmacy, Toxicology Department, Ankara, Turkey.
Mutation Research
|April 1, 1994
Abstract:
Sister-chromatid exchange (SCE) analysis was carried out in different age groups prior to and after therapy with 8-Methoxypsoralen (8-MOP) followed by exposure of the patient to long-wave UV-A (PUVA) and compared to control. The SCE frequencies were increased significantly in PUVA-treated patients as compared to their pre-treatment SCE levels and to controls. A significant increase in SCEs was found in smoking PUVA-treated patients as compared to non-smoking PUVA-treated patients. This study indicates a detectable chromosome-damaging effect of PUVA therapy on its human users.