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Lung function in acromegaly

B D Harrison, K A Millhouse, M Harrington

The Quarterly Journal of Medicine

|October 1, 1978

Summary

This summary is machine-generated.

Acromegaly (excess growth hormone) can cause lung and airway problems, especially with longer disease duration. Early treatment is recommended to prevent lung function abnormalities.

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Area of Science:

Pulmonary Medicine
Endocrinology

Background:

Acromegaly, a condition caused by excess growth hormone, can lead to various systemic complications.
The impact of acromegaly on lung function and airway dynamics is not fully understood.

Purpose of the Study:

To investigate the relationship between the duration of acromegaly and lung function abnormalities.
To assess the incidence of small airways narrowing and upper airway narrowing in patients with acromegaly.

Main Methods:

Spirometry, body plethysmography, flow volume loops, and single breath transfer factor were used to assess lung function in 30 acromegaly patients.
Patients with kyphosis or pulmonary venous hypertension were excluded for specific analyses.

Main Results:

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A significant correlation was found between acromegaly duration and total lung capacity.

Small airways narrowing was observed in 8 patients, with a significantly longer disease duration compared to those without narrowing.

Upper airway narrowing was present in 5 male patients, often associated with longer acromegaly duration.

Conclusions:

Increased total lung capacity, small airways narrowing, and upper airway narrowing are linked to the duration of acromegaly.
Patients with acromegaly exceeding eight years are at higher risk for lung function abnormalities.
Early treatment of acromegaly is suggested to mitigate pulmonary complications.